When: Jul 17, 2018 - 12:00pm - 1:00pm
Location: DHMC - Borwell Room 658W
Description: Please join us for this first seminar in the series:
Summer 2018 - Center for Imaging Medicine Optics Seminars
And enjoy some pizza (served at 11:45, first-come, first served!)
With more than 80,000 new cases per year, India has one of the highest incidence rates of oral cancer in the world, driven by widespread popularity of chewing carcinogenic tobacco and betel leaf mixtures. Described as a global health crisis, insufficient medical infrastructure for timely surgery and radiotherapy exacerbates this situation, especially in rural areas. Early clinical studies indicate ALA photodynamic therapy (PDT) for oral cancers may be effective and conducive to adaptation for global implementation. We developed low-cost user-friendly devices for enabling ALA PDT and associated imaging applications specifically for resource-limited settings. The system includes a compact, battery-powered, fiber-coupled 635nm LED light source for activation of protoporphyrin IX (PpIX), combined with a kit of interchangeable bite blocks and 3D printed applicators with pre-calibrated dosimetry of varying oral lesion positions and sizes. For treatment guidance, the system uses a simple smartphone-mounted LED array and emission filter for imaging PpIX fluorescence to locate approximate lesion boundaries and assess photobleaching. This technology is being evaluated currently in early-stage oral cancer patients in Aligarh, India. I will discuss lessons learned in initial clinical implementation and ongoing device development and optimization. In addition to meeting design criteria for global health implementation, the intraoral light-delivery system provides predictable dosimetry and improved ergonomics with the potential to improve feasibility and usability of PDT treatment of oral lesions in any clinical setting.