Project: Ex-Tissue Resident Memory T-cells for the Diagnosis and Monitoring of Chronic Graft versus Host Disease
Patrick's clinical and research focus is on allogeneic stem cell transplantation (ASCT) and graft versus host disease (GVHD). He uses single- cell analysis of patient samples to understand the immunology of ASCT and pathogenesis of GVHD. His work centers on understanding tissue-based donor T-cell immune reconstitution and its role in GVHD, as well as identifying peripheral blood T-cell populations that reflect tissue-based donor T-cell immune reconstitution and its role in GVHD, as well as identifying peripheral blood T-cell populations that reflect tissue based immunopathology.