The SYNERGY Translational Pilot Award Program supports innovative, early-stage translational research that accelerates scientific discoveries into real-world solutions to improve rural health and healthcare delivery.
Through competitive funding, SYNERGY invests in innovative, cross-disciplinary translational science that accelerates scientific discoveries into real-world solutions to improve rural health and healthcare delivery. Pilot awards enable investigators to generate preliminary data, evaluate novel approaches, and strengthen competitiveness for future NIH, NCATS, and foundation funding.
Dartmouth CTSI (SYNERGY) Translational Pilot Program_LOI Portal
📝 LOI Deadline: September 4, 2026 | 11:59 PM ET
Program Overview
SYNERGY Translational Pilot Awards — At a Glance
- Award Amount: $20,000–$50,000 total direct costs
- Project Duration: 12 months
- Eligibility: Dartmouth-affiliated investigators (Multiple PI required)
- Anticipated Start Date: July 1, 2027
Questions? Contact: synergy@dartmouth.edu
Apply Now
2026 Application Materials and Supporting Documents
- SYNERGY Request for Applications (RFA) – 2026–2027
- SYNERGY Letter of Intent (LOI) Template - 2026 -2027
- Available Soon_Application template and budget worksheet - 2026-2027
- 2026 Informational Slide Deck Dartmouth CTSI (SYNERGY)
- Available Soon_2026 Informational Session Video Dartmouth CTSI (SYNERGY)
Program Priorities
Competitive proposals demonstrate scientific innovation, translational relevance, and the potential for meaningful impact. Community engagement is strongly encouraged, particularly for research addressing rural health needs.
Translational Impact
- Clear translational potential with defined pathways to clinical or community application
- Innovative approaches that address barriers in translational research
Collaboration & Alignment
- Meaningful cross-disciplinary collaboration
- Relevance to rural and population health priorities
Sustainability
- High likelihood of securing future external funding
- Potential to inform future clinical practice, policy, or research
SYNERGY Pilot Awardees (Cohort Year 2)
SYNERGY is proud to support pioneering research across clinical medicine, engineering, public health, and implementation science.
Jeffery C. Munson, MD, MSCE
Associate Professor in the Department of Medicine and at the Dartmouth Institute for Health Policy and Clinical Practice
Project: Biomarkers at the Bedside: Neutrophil Signatures for Precision Steroid Use in Septic Shock
Jeffery C. Munson, MD, MSCE is an Associate Professor in the Department of Medicine and at the Dartmouth Institute for Health Policy and Clinical Practice. He is a critical care physician and the Director of the Medical Intensive Care Unit at Dartmouth. His research is in the field of pharmacoepidemiology focused primarily on the prescribing behavior of practicing physicians and the adverse effects of prescription drugs. He has a specific interest in the use of corticosteroids across a variety of patient conditions.
Jennifer Hong, MD
Neurosurgeon, working at the intersection of spatial transcriptomics and neuroscience
Project: Human organotypic brain slice culture for elucidation interest in the use of corticosteroids across a variety of of glioma immunology
Jennifer Hong, MD is a Neurosurgeon, working at the intersection of spatial transcriptomics and neuroscience. She is currently pursuing research evaluating the role of brain extracellular matrix in brain tumor-related epilepsy and is thrilled to be participating in the Synergy Pilot Program.
Patrick W. Mellors, MD
Assistant Professor of Hematology at Norris Cotton Cancer Center
Project: Ex-Tissue Resident Memory T-cells for the Diagnosis and Monitoring of Chronic Graft versus Host Disease
Patrick W. Mellors, MD is an Assistant Professor of Hematology at Norris Cotton Cancer Center. His clinical and research focus is on allogeneic stem cell transplantation (ASCT) and graft versus host disease (GVHD). He uses single- cell analysis of patient samples to understand the immunology of ASCT and pathogenesis of GVHD. His work centers on understanding tissue-based donor T-cell immune reconstitution and its role in GVHD, as well as identifying peripheral blood T-cell populations that reflect tissue-based donor T-cell immune reconstitution and its role in GVHD, as well as identifying peripheral blood T-cell populations that reflect tissue based immunopathology.
Renata W. Yen, PhD
Senior Research Scientist at the Center for Technology and Behavioral Health and the Department of Biomedical Data Science at Dartmouth’s Geisel School of Medicine
Project: ProYou: Development of a Digital Intervention to Meet the Mental Health and Decision-Making Needs of People with Pelvic Organ Prolapse
Renata W. Yen, PhD is a Senior Research Scientist at the Center for Technology and Behavioral Health and the Department of Biomedical Data Science at Dartmouth’s Geisel School of Medicine. As a health services researcher, she is focused on decision-making interventions and patient-clinician communication, specifically in the field of women’s health.
Ryan E. Little, MD,
Assistant Professor of Surgery at Dartmouth Health and Director of the Sinus Research Center
Project: In Vivo Imaging of Olfactory Epithelium in Humans with Olfactory Impairment Using Confocal Laser Endomicroscopy
Ryan E. Little, MD is an Assistant Professor of Surgery at Dartmouth Health and Director of the Sinus Research Center, is developing a novel objective imaging approach to evaluate olfactory dysfunction in living patients. His SYNERGY Translational Pilot Award supports pioneering use of confocal laser endomicroscopy (CLE) to visualize the olfactory epithelium in real time, pairing high-resolution cellular imaging with validated psychophysical smell testing and patient-reported measures.
Sladjana Skopelja-Garnder, PhD
Assistant Professor of Microbiology and Immunology and an Assistant Professor of Medicine at the Geisel School of Medicine at Dartmouth
Project: Preclinical development of a MAIT cell-targeted topical therapy for lupus skin Disease
Sladjana Skopelja-Gardner, PhD is an Assistant Professor of Microbiology and Immunology and an Assistant Professor of Medicine at the Geisel School of Medicine at Dartmouth. She earned her bachelor’s degree in biochemistry from Dartmouth College, completed her PhD in Immunology at Geisel School of Medicine, and conducted postdoctoral training at the University of Washington studying innate immune mechanisms in lupus.
View Past Cohorts
Eligibility & Requirements
Collaboration & Institutional Requirements
The program welcomes:
- Early-stage investigators launching translational research programs
- Established investigators pursuing novel directions
- Collaborative teams spanning departments, schools, or partner institutions
Approval Requirements
Applicants must include a Dartmouth-affiliated Multiple Principal Investigator.
Application & Proposal Preparation
All Applicant Resources
All materials provide detailed guidance on eligibility, budget development, review criteria, and submission requirements.
- Dartmouth CTSI Pilot Awards - Request for application (RFA) 2026
- Dartmouth CTSI Pilot Awards - Letter of Intent (LOI) 2026
- Dartmouth CTSI_NCATS Pre approval Common Instructions
- Recorded Webinar Presentation
- NIH Clinical Trial Definitions & Guidance
Prepare a Competitive Proposal
Investigators are encouraged to begin planning early to allow sufficient time for:
- Building cross-disciplinary partnerships
- Developing a realistic and compliant budget
- Planning regulatory submissions
- Establishing community collaborations where appropriate
The SYNERGY Pilot Award team is available to support investigators throughout the preparation process.
Why Apply?
SYNERGY Pilot funding provides more than financial support — it serves as a launchpad for high-impact research programs.
Our goal is to empower investigators to move promising discoveries forward, faster and more effectively.
Awardees benefit from:
- Critical early-stage funding
- Enhanced competitiveness for external grants
- Access to institutional expertise and research infrastructure
- Opportunities for interdisciplinary collaboration
Dartmouth CTSI (SYNERGY) Translational Pilot Award FAQs
Both the Contact PI and MPI must have a Dartmouth academic appointment at the level of Instructor or Research Scientist or above to apply. If you have been struggling to identify collaborators, we would recommend reaching out to the leadership of Dartmouth affiliated-schools and/or departments to request their assistance.
Yes. As stated in the RFA, all investigators must hold academic appointments at Dartmouth. This requirement applies to both the Contact PI and the MPI.
Dartmouth Health staff scientists who do not hold Dartmouth academic appointments are not eligible to serve as MPIs but may participate as collaborators. If a Dartmouth Health staff scientist does hold a Dartmouth academic appointment, they are eligible to serve as an MPI.
MPIs must represent 2 different academic disciplines or 2 different departments or schools.
Applicants may be Contact Principal Investigator for one submission only. An applicant may be an MPI on more than one submission.
No, however, they may participate as team members on pilot projects.
Professors may serve as MPIs or mentors but cannot be Contact PIs on pilot awards.
Salary support is permitted but cannot exceed the NIH salary cap. For more information, please see: https://grants.nih.gov/grants/guide/notice-files/NOT-OD-24-057.html.
Small equipment purchases (<$5000) will be considered on a case by case basis.
NCATS offers several resources describing translational science principles. We recommend that applicants map their proposed research to these principles when it is feasible to do so: https://ncats.nih.gov/about/about-translational-science/principles.
Professors may serve as MPIs or mentors but cannot be Contact PIs on pilot awards.
Yes. When both the Contact PI and MPI are junior faculty members, the required mentor should have a Dartmouth affiliation.
Resources and tools for engagement can be found here: https://catalyst.harvard.edu/community-engagement/ce/.
- For information about research data, EHR, REDCap, Granite, or other research informatics systems, please see the SYNERGY Data & Informatics page. Please read the SYNERGY Research Data Handbook.
- For more help, complete the SYNERGY Informatics Consultation Request form.
- To receive biostatistical consultation, please complete the Biostatistics Consultation Request Form.
For support in writing and framing your project, please free to reach out to GrantGPS at grantgps@dartmouth.edu.
Projects selected for funding via this mechanism will be sent to the NIH for review and approval before the project can begin.
Get in Touch
For questions related to the SYNERGY Translational Pilot Award, please contact Ruchir Goswami.